2000280
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Isohemagglutinin Titer, IgG and IgM

IRL ISO MG
Example Reports
Group A
Group B

Ordering Recommendation

Aid in determination of the relative amount of anti-A or anti-B present in plasma. Higher titers may be used in the evaluation of an individual's ability to mount an immune response against the cognate antigens. IgG isohemagglutinin titers cannot be performed in patients who have received monoclonal antibodies known to interfere with immunohematology testing including but not limited to andi-CD38 and anti-CD47. These monoclonal therapies interfere with testing, causing invalid IgG titer results.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Lavender (K2EDTA), or Pink (K2EDTA).

Specimen Preparation

Do not freeze. Transport 14 mL whole blood. (Min: 6 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Separator or gel tubes.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Unacceptable

Methodology

Qualitative Hemagglutination (HA)

Performed

Mon-Fri

Reported

1-3 days

Reference Interval

Normals are not applicable.

Interpretive Data



Compliance Category

Standard

Note

Isohemagglutinin titers contain both IgM and IgG. Both IgG and IgM titers will be performed for this test. If only IgM or IgG titer is desired, order Isohemagglutinin Titer, IgG (2000271) or Isohemagglutinin Titer, IgM (2000270). Specimens are screened for antibodies; if positive, antibody identification will be performed. Titers will be performed as indicated by the isohemagglutinins detected. Additional charges will apply to antibody identification and titer testing.

Hotline History

N/A

CPT Codes

86900; if blood type is A add: 86886, 86941; if blood type is B, add: 86886, 86941; if blood type is O, add: 86886 x2, 86941 x2. If blood type is AB, no additional titers will be performed.

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Components

Component Test Code* Component Chart Name LOINC
2000288 ABO Group ISO Interp 883-9
2000289 Anti A Titer IgM ISO 50762-4
2000290 Anti B Titer IgM ISO 50763-2
2000295 Anti A Titer IgG ISO 50761-6
2000296 Anti B Titer IgG ISO 50764-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Anti-A & B Titer
  • Isohemagglutinin Titer Anti-A
  • Isohemagglutinin Titer Anti-B
Isohemagglutinin Titer, IgG and IgM